Abstract
IntroductionCytofluorographic and molecular techniques are effective adjuncts in diagnosing intraocular lymphoma. Primary intraocular lymphoma is an uncommon entity predominantly of B cell origin and rarely with a T cell phenotype. The aim of the present paper is to report a case of a CD8-positive, TCR-α/β-negative intraocular T cell lymphoma and review the literature.Case presentationT cell neoplasia was detected based on flow cytometric demonstration of an abnormal T cell population and polymerase chain reactions for immunoglobulin and T-cell receptor rearrangements demonstrating evidence of monoclonality. Flow cytometry revealed a T cell population aberrantly expressing T-cell lineage markers. This T cell population expressed CD2, bright CD3, CD8, bright CD7, CD38, CD69, and variable CD25. T-cell receptor γ gene rearrangement studies demonstrated evidence of T-cell gene rearrangement confirming that the T cells were monoclonal.ConclusionWe herein report the rare case of a TCR α/β-negative CD8+ intraocular T-cell lymphoma suggestive of gamma/delta origin diagnosed by flow cytometry and polymerase chain reaction.
Highlights
Cytofluorographic and molecular techniques are effective adjuncts in diagnosing intraocular lymphoma
The occurrence of intraocular lymphoma can be divided into metastatic lymphoma to the eye usually presenting as uveal small cell non Hodgkin lymphoma, or primary intraocular lymphomas (PIOL) that characteristically are vitreoretinal large B cell variety [1]
Patients with the latter disease sometimes have a history of mycosis fungoides, systemic T cell lymphoma/ leukemia, acquired immunodeficiency syndrome, or infection with human T cell lymphotropic virus type I [1]
Summary
Cytofluorographic and molecular techniques are effective adjuncts in diagnosing intraocular lymphoma. The aim of the present paper is to report a case of a CD8-positive, TCR-α/β-negative intraocular T cell lymphoma and review the literature. Case presentation: T cell neoplasia was detected based on flow cytometric demonstration of an abnormal T cell population and polymerase chain reactions for immunoglobulin and T-cell receptor rearrangements demonstrating evidence of monoclonality. Flow cytometry revealed a T cell population aberrantly expressing T-cell lineage markers. The vast majority of intraocular lymphomas are composed of B cells with T cell lymphomas being rare Patients with the latter disease sometimes have a history of mycosis fungoides, systemic T cell lymphoma/ leukemia, acquired immunodeficiency syndrome, or infection with human T cell lymphotropic virus type I [1]. TCR rearrangement in ocular T cell lymphomas has not been well studied or described
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