Abstract
Abstract: The ability of HIV-1 Vpr to kill human cells has been shown to be due to the sequence, HFRIGCRHSRIG, comprising Vpr amino acid residues 71-82. In this study cell killing by Vpr equivalents in other primate lentiviruses has been examined. Five purified synthetic peptides, related to the bioactive region ofHIV-1 Vpr and derived from HIV-2 Vpr and Vpx, SIVmac Vpr and Vpx, and SIVagm Vpx, were shown to share similar abilities to penetrate and kill cells.
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