Abstract

Abstract The application of molecular biology to the study of cytochrome P450 has resulted in the elucidation of more than 150 primary sequences within this superfamily of hemoproteins. Only a single tertiary structure, howeve r, has been solved: that of the soluble bacterial cytochrome P450cam. Major questions that remain involve the topology of eukaryotic P450s in cellular membranes and whether or not amino acids that contact the substrate (camphor) in P450cam can be used as guideposts in the identification of substrate-binding sites in all other P450s.

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