Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women

Aesun Shin,Keun-Young Yoo,Sue Kyung Park,Ji-Yeob Choi,Sei-Hyun Ahn,Kyoung-Mu Lee,Daehee Kang,Dong-Young Noh

doi:10.1038/emm.2007.40

Aesun Shin, Keun-Young Yoo + Show 6 more

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https://doi.org/10.1038/emm.2007.40

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Abstract

Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. We evaluated the associations between two CYP1A1 polymorphisms [MspI (rs4646903); Ile462Val (rs1048943)] and breast cancer in a multicenter case-control study of 513 breast cancer cases and 447 controls in Korea. Women carrying the T allele of the CYP1A1 MspI polymorphism were found to have a 1.72-fold (95% CI 1.11-2.68) greater risk of developing breast cancer. No association was found between any CYP1A1 Ile462Val polymorphism and breast cancer. Haplotype analysis of the two loci showed that the CA haplotype was associated with the lowest risk of breast cancer, and CA/CA diplotypes were associated with a lower risk of breast cancer [OR=0.28 (0.13-0.61)] than others/others diplotypes. Moreover, this reduced risk was more pronounced among women with a lower body mass index (BMI) [OR=0.18 (0.06-0.58)] or with a shorter lifetime exposure to estrogen [OR=0.23 (0.07-0.81)]. The results obtained suggest that the CYP1A1 MspI polymorphisms could affect susceptibility to breast cancer.

Highlights

Genes involved in estrogen metabolism are prime targets of breast cancer etiological studies, because estrogen and its metabolites play critical roles in breast cancer initiation and promotion (Service, 1998; Zhu and Conney, 1998)
Our results suggest that Cytochrome P450 1A1 (CYP1A1) MspI polymorphisms may affect breast cancer susceptibility in Korean women, and haplotype analysis may provide more information on the risk assessment
Several studies have been conducted on the association between polymorphisms of the CYP1A1 gene and breast cancer risk (Ambrosone et al, 1995; Taioli et al, 1995; Bailey et al, 1998; Ishibe et al, 1998; Huang et al, 1999; Basham et al, 2001; Krajinovic et al, 2001; da Fonte de Amorim et al, 2002; Laden et al, 2002; Miyoshi and Noguchi, 2003; Hefler et al, 2004; Li et al, 2004; Boyapati et al, 2005; Masson et al, 2005)

Summary

Introduction

Genes involved in estrogen metabolism are prime targets of breast cancer etiological studies, because estrogen and its metabolites play critical roles in breast cancer initiation and promotion (Service, 1998; Zhu and Conney, 1998). The CYP1A1 Ile462Val polymorphism in exon 7 and the T6235C polymorphism on the 3' non-coding region (MspI) have been intensively studied in relation to breast cancer risk (Ambrosone et al, 1995; Taioli et al, 1995; Bailey et al, 1998; Ishibe et al, 1998; Huang et al, 1999; Basham et al, 2001; Krajinovic et al, 2001; da Fonte de Amorim et al, 2002; Laden et al, 2002; Miyoshi and Noguchi, 2003; Hefler et al, 2004; Li et al, 2004; Boyapati et al, 2005; Masson et al, 2005). We evaluated the potential association between two polymorphisms of the CYP1A1 gene and breast cancer risk in Korean women

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