Abstract
Evidence was obtained that fumagillin inhibits RNA synthesis in the microsporidian, Octosporea muscaedomesticae, a pathogen of the blow fly, Phormia regina. Infections, treated with 66 mg fumagillin per liter of 5% sucrose for six hours, were compared to control octosporeoses of the same age with the following techniques: Giemsa stain, pyronin-methyl green, and acridine orange fluorescence. Staining reactions demonstrated an almost complete loss of material from the parasites' cytoplasm; RNase treatment of normal parasites identified this material as RNA. Parasite DNA remained unchanged after fumagillin treatment, as observed by the above techniques.
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