Cytochalasin B: Effect on mammalian cardiac muscle cells in culture

Abstract

The effect of cytochalasin B on mammalian cardiac cells in culture was studied at 1 μg/ml and 5 μg/ml cytochalasin B. When cells were grown in the presence of cytochalasin B their morphology was altered and cytokinesis inhibited, but the cells continued to contract, often at an increased rate. The adhesiveness of the cells to the culture dish was increased, suggesting a membrane effect of cytochalasin B, rather than an effect on the contractile machinery.