Abstract
Abstract Objective To study the histomorphological changes with reference to estradiol valerate administration in aged female albino rats. Methods The observations showed in young, aged and aged administered with estradiol valerate (Progynova tablets) at the dose of 2 mg/day through oral gavages for one week. The histomorphological changes were observed in ovary, uterus, vagina and liver. Results Estradiol velerate administration improves the ovarian stroma and germinal epithelium. The vascular hyaline degeneration reduces. Vascular protective effects of estrogen are well established. The administration may be associated with endometrial hyperplasia and neoplasia. The stroma was comparatively less edematous with less active endometrial glands. The uteri exhibited endometrial epithelial cell pseudo stratification and hypertrophy. The vaginal histoarchitecture showed increased epithelial proliferation of the vaginal wall and improving thickening. Estradiol velerate does not showed any effect on liver architecture. Conclusions The administration of estradiol valerate showed its vascular protective effects. It does not showed any effect on liver architecture.
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