Cystoid macular edema with prostaglandin analogue use after uneventful cataract surgery in glaucoma patients

Abstract

To evaluate the effect of postoperative latanoprost administration on central macular thickness (CMT) after uneventful cataract surgery in glaucoma patients. Farabi Eye Hospital, Tehran, Iran. Prospective randomized clinical trial. In this single-masked trial, glaucoma patients treated with latanoprost who had no other risk factor for the development of pseudophakic macular edema were randomly allocated to continuation of latanoprost or discontinuation of the drop after uneventful cataract surgery. At baseline and postoperatively at 1month and 3months, patients had complete ocular examinations and CMT measurements using optical coherence tomography. The main outcome measure was the change in the CMT between baseline measurements and postoperative measurements at 1month and 3months. One hundred fifty-six eyes (latanoprost 76; discontinuation 80) finished the trial. There were no differences in baseline patient demographics or characteristics, including the CMT, between the two groups. There was transient increase in the mean CMT by 12μm±49 (SD) in the latanoprost group at 1month (P=.03); however, the value returned to baseline by 3months (6±55μm; P=.27). The between-group difference in the mean change in the CMT from baseline was -3.1μm (95% confidence interval [CI], -18.4 to 12.0; P=.68) after 1month and -10.5μm (95% CI, -26.6 to 5.5; P=.19) after 3months; the differences were not significant. Latanoprost administration after cataract surgery had no measurable effect on macular thickness.