Cystine-based MBioF for Maintaining the Antioxidant-Oxidant Balance in Airway Diseases.

Abstract

Reactive oxygen species, contributing to oxidant-antioxidant imbalance, initiate damage to the airways cells, inflammatory processes, and further pathophysiological effects. Enhancing antioxidant properties is the main prophylactic and therapeutic challenge. In this work, a newly synthesized and biocompatible structure of the metal-biomolecule frameworks (MBioF) harnessing cystine as a linker and magnesium as metal nodes is presented. This structure provides crucial sulfhydryl groups of cysteine, with antioxidant activity, released stepwise in the site of delivery. We prove that once released, the compounds of MBioF increase the intracellular level of cysteine and total antioxidative capability of airway cells. Presented MBioF structures offer new perspectives for clinical applications as therapeutics or preventatives maintaining the antioxidant-oxidant balance.