Cysticlean® a highly pac standardized content in the prevention of recurrent urinary tract infections: an observational, prospective cohort study.

Francisco Sánchez Ballester,Emilio López Alcina,Cristina Domenech Perez,Vicente Ruiz Vidal,Ana Montoliu García,Marco Sobrón Bustamante,Ana Oltra Benavent,Eva Escudero Fontano

doi:10.1186/1471-2490-13-28

Abstract

BackgroundThe present study was aimed at determining the prophylactic efficacy of American cranberry (AC) extract (Cysticlean®) in women with recurrent symptomatic postcoital urinary tract infections (PCUTI), non-consumer of AC extract in the past 3 months before inclusion, and to determine changes in their quality of life (QoL).MethodsThis was a single center, observational, prospective study in a total of 20 women (mean age 35.2 years; 50.0% were married). Patients were followed up for 3 and 6 months during treatment.ResultsThe number of PCUTIs in the previous 3 months prior to start the treatment with Cysticlean® was 2.8±1.3 and it was reduced to 0.2±0.5 at Month 6 (P<0.0001), which represent a 93% improvement. At baseline, the mean score on the VAS scale (range from 0 to 100) for assessing the QoL was 62.4±19.1, increasing to 78.2±12.4 at Month 6 (P=0.0002), which represents a 20% improvement. All patients had an infection with positive urine culture at baseline, after 6 months there were only 3 symptomatic infections (P<0.001). The most common bacterium was Escherichia coli.ConclusionsProphylaxis with American cranberry extract (Cysticlean®) could be an alternative to classical therapies with antibiotics. Further studies are needed to confirm results obtained in this pilot study.

Highlights

The present study was aimed at determining the prophylactic efficacy of American cranberry (AC) extract (Cysticlean®) in women with recurrent symptomatic postcoital urinary tract infections (PCUTI), non-consumer of AC extract in the past 3 months before inclusion, and to determine changes in their quality of life (QoL)
The high prevalence of urinary tract infections (UTIs) causes a major social and health impact. 37% of women suffer at least one episode of cystitis during their lifetime, of these, 20% recur in the first two months due to poor cure of infection, resistance to antibiotics or poor hygiene habits
The study included women aged 18 to 60 years old, with at least two PCUTIs due to E. coli in the past year and with active infection confirmed by symptomatic positive urine culture to E. coli at the beginning of the study

Summary

Introduction

The present study was aimed at determining the prophylactic efficacy of American cranberry (AC) extract (Cysticlean®) in women with recurrent symptomatic postcoital urinary tract infections (PCUTI), non-consumer of AC extract in the past 3 months before inclusion, and to determine changes in their quality of life (QoL). 37% of women suffer at least one episode of cystitis during their lifetime, of these, 20% recur in the first two months due to poor cure of infection, resistance to antibiotics or poor hygiene habits. The most common causes include: alteration of the vaginal flora, cold and humidity, low insertion of the urethral meatus, chronic constipation, lack of. To deal with this situation, different therapeutic options have been proposed. The possibility of administering antibiotic prophylaxis temporarily can be considered, though given the gradual increase in the number of antibiotic resistances of the most common pathogens, the current trend is to search for other options [2]

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