Abstract
Cystic changes in fetal kidneys following ureteral ligation: Studies by microdissection. Intrauterine ureteral ligation of fetal rabbits is followed by the development of dilatation of collecting ducts and dilatation or cyst formation in nephrons in the obstructed kidneys or both. Microdissection reveals the presence of cysts in various portions of the nephron, the most striking being localized in the loop of Henle and, particularly, at the bend of the loop. The cysts of the loop of Henle in fetal rabbit kidneys are similar to those so frequently encountered in microdissection studies of human cystic kidneys. The unquestioned relationship of the experimental cysts to pressure effects gives insight into one mechanism for the causation of the human cysts. The cysts of loop of Henle which occur in the presence of urinary tract obstruction in human kidneys are readily explained. In the absence of urinary tract obstruction, however, the cysts of nephrons of certain human kidneys may result from local obstruction to individual nephrons by pressure of contiguous cysts of collecting ducts.
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