Abstract
Abstract Cysteine-cysteine chemokine receptor 5 (CCR5) is a protein found on the surface of CD4 cells which Human immunodeficiency virus (HIV-1) uses as a co-receptor when entering the host’s target cells. There is a variant of CCR5 known as CCR5 delta 32 that results due to a deletion mutation. CCR5 delta 32 plays an important role in the acquisition of HIV-1 and progression to AIDS. This study was done to determine the CCR5 genotype of HIV positive patients attending Heart to Heart clinic in Federal Medical Centre, Yenagoa, Bayelsa State. A total of 50 whole blood samples were collected by simple random sampling from 50 HIV positive patients attending Heart to Heart clinic in Federal Medical Centre, Yenagoa, Bayelsa State. DNA was extracted from each sample using ZR mini prep DNA extraction kit. CCR5 gene in each DNA extract was amplified by polymerase chain reaction on a 9700 ABI Thermo Cycler and then resolved on 1% agarose gel electrophoresis. Out of the 50 samples examined, 50 (100%) were homozygous for the normal CCR5 gene, 0(0%) were homozygous for the CCR5 delta 32 gene and no heterozygosity was recorded. This study revealed a very low or absence of CCR5 delta 32 deletion gene among HIV patients in Yenagoa suggestive of their rapid progression towards AIDS if other measures are not observed.
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