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Abstract
Background: The aim of the present study was to examine the diagnostic capacity of this new parameter towards early signs of renal disease in patients suffering from prolonged RA requiring potential nephrotoxic therapy.
 Methods: The present study was a cross sectional observational type of study conducted in the department of medicine Mathura Das Mathur Hospital, Dr. S.N. Medical College, Jodhpur. A total of 50 subjects that fulfilled the inclusion and exclusion criteria were enrolled in the study after informed and written consent. As per methodology complete blood count, ESR, liver function test, kidney function test, cystatin-c, urine complete, 24 hours urine creatinine, USG abdomen for kidney size were performed.
 Results: cystatin–C level below 0.95 mg/dl was considered normal. 19 patients have normal and 31 patients have abnormal more than 0.95 mg/dl.
 Conclusion: In conclusion, as compared to serum creatinine, the determination of serum cystatin C is comparably simple, but by far more sensitive for the diagnosis of incipient renal damage in RA, and therefore valuable for clinical screening particularly in cases with prolonged antirheumatic treatment.
 Keywords: Cystatin C, RA, KFT
Highlights
Rheumatoid arthritis (RA) is a chronic disease requiring long–term therapy with nonsteroidal anti–inflammatory drugs (NSAID) and disease modifying antirheumatic drugs (DMARD)
Background: The aim of the present study was to examine the diagnostic capacity of this new parameter towards early signs of renal disease in patients suffering from prolonged RA requiring potential nephrotoxic therapy
Serum Creatinine e Figure 2: Receiver operating characteristic (ROC) plot was prepared to assess the diagnostic efficacy of serum creatinine for early detection of renal dysfunction with normal and abnormal GFR
Summary
Rheumatoid arthritis (RA) is a chronic disease requiring long–term therapy with nonsteroidal anti–inflammatory drugs (NSAID) and disease modifying antirheumatic drugs (DMARD). The fact that it is a longstanding disease and prolonged antirheumatic treatment Recent studies have shown that plasma Cystatin–C reflects glomerular filtration rate (GFR) better than serum creatinine, blood urea nitrogen since the later is affected by many nonrenal factors, such as muscle mass, hydration, physical activity, body surface area, sex, and age 2.
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