Abstract
Objective: This study was planned to study serum cystatin C (CysC) levels in sick neonates admitted in neonatal intensive care unit (NICU) with predisposing risk factor(s) for development of acute kidney injury (AKI). We evaluated serum levels of CysC and creatinine in sick neonates. Methods: Ninety-four sick neonates with prematurity, sepsis, respiratory distress, and/or perinatal asphyxia requiring NICU admission were enrolled. Serum levels of creatinine and CysC were measured on day 3 of life. Results: Serum levels of both cystatin C and creatinine were significantly elevated in neonates who developed AKI versus those who did not (CysC: 2.18 ± 0.59 vs. 1.91 ± 0.47 mg/dl, P = 0.04; creatinine: 1.68 ± 0.75 vs. 0.89 ± 0.40, P
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