Abstract
Correction: On the website, on 16/08/2014, the first author was changed from Md Aminul Khan TO Md Aminul Haque Khan. The PDF was correct.The most widely used investigation of renal function and GFR is the measurement of serum creatinine and creatinine clearance rate. This has been extremely popular in clinical medicine despite formidable difficulties associated with its quantification and interpretation. The main pathophysiological difficulties include variations in the rates of creatinine generation and its secretion by the renal tubules. Concentration of serum creatinine is now recognized as an unreliable measure of kidney function as it is affected by age, body weight, muscle mass, race and various medications. Several equations have been developed to improve the accuracy of serum creatinine level as a measure of GFR. The most widely used in adult populations are the Cockroft-Gault equation and the abbreviated Modification of Diet in Renal Disease (MDRD) equation. Even with these equations, measurement of GFR is difficult because the equations are less accurate with higher levels of kidney function and are affected by interlaboratory variation in measuring creatinine level. In the above perspective, cystatin C concentration has become a promising marker for kidney function in both native and transplanted kidneys. Because of the possible potentiality of cystatin C to be an emerging endogenous marker for quick and accurate assessment of renal function, we have decided to review elaborately on cystatin C as a marker of renal function and to review the sensitivity and specificity of cystatin C as an endogenous marker compared to serum creatinine. Results of our review study suggest that cystatin C is a better marker of renal function compared to serum creatinine and other endogenous markers irrespective of age, sex and clinical condition. DOI: http://dx.doi.org/10.3329/jemc.v4i2.19680 J Enam Med Col 2014; 4(2): 110-122
Highlights
The social and economic consequences of chronic renal failure are considerable.[1]
Concentration of serum creatinine is recognized as an unreliable measure of kidney function because it is affected by age, body weight, muscle mass, race
As muscle mass falls and glomerular filtration rate (GFR) is the measurement of serum creatinine and with age, less creatinine is produced each day
Summary
The social and economic consequences of chronic renal failure are considerable.[1]. Acute renal failure (ARF) defined by a rapid decrease of glomerular filtration rate (GFR) is associated with high interpretation.[3]. The trends for three commonly used creatinine-based estimates of GFR compared poorly with trends in iothalamate clearance (r < 0.35).[29] the investigators concluded that serial measures of serum cystatin C accurately detect trends in renal function in patients with normal or elevated GFR and provide means for studying early renal function decline in diabetes.[29]. Statistical analysis suggested that cystatin C and cystatin C-based calculated GFR was equivalent but not better than serum creatinine and Schwartz formula They concluded that measurement of cystatin C could be used for followup of renal function of pediatric solid organ posttransplants.[43] All these studies on pediatric populations are consistent with each other and recommend cystatin C as a useful renal function marker in pediatric populations in different settings. They concluded that the use of cystatin C and creatinine combination equation for estimating GFR in a multi-ethnic Asian population with CKD does not require ethnicity coefficients as the derived coefficients are very close to each other
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
