Abstract
The new risk-factors for peptic ulcers induced by the use of nonsteroidal antiinflammatory drugs, such as polymorphism of different isoenzymes of cytochrome P450 were considered in the article. The aim of the research was to study different genetic polymorphism of several ferments CYP2C9 and CYP2C19 in inclination to NSAIDS-gastropathies by the way of estimation the risk of appearance of Helicobacter pylori (HP)-positive or Hp-negative NSAIDS- induced peptic ulcers, complicated or not with upper gastrointestinal bleeding. 124 persons were examined (76 men, 48 women in the age of 56,2+/–9,1 years) with Hp-positive or Hp-negative NSAIDS-induced peptic ulcers, that were performed genotyping of isoferments of cytochrome system (CYP2C9, CYP2C19). Based on investigations of 5 different isoenzymes (CYP 2C9*2, CYP 2C9*3, CYP 2C19*2, CYP 2C19*3 and CYP 2C19*17). It was founded that peptic ulcers are strictly associated only with CYP 2C19*17-genotype, possibly due to its involvement in arachidonic acid metabolism and gastroprotection. Thus, polymorphism CYP 2C19*17 can be considered as one of the risk factors for NSAID-gastropathy though the future researches are needed.
Highlights
Nonsteroidal anti-inflammatory drugs (NSAIDs)-is one of highly used drugs, taken by 30 million of people every day
NSAIDs-gastropathies are erosive ulcerative affects of gastroduodenal zone, that appear during the use of NSAIDs and aspirin and have a specific cilinic an endoscopic picture.Their diagnostic criteries are chronologic connection with the usage of NSAIDs, the lack of symptoms, blurring clincal picture, the high risk of bleeding manifistation, acute and often numerous injuries, preferred location in antral part of a stomach, the absence of inflammatory wave around the ulcers, foveolar hyperplasia of mucose and quite quick healing, when NSAIDs cancelled
Helicobacter pylory infection (Hp)-positive or Hp-negative NSAIDS-induced peptic ulcers, that underwent genotyping of isoenzymes of cytochrome system (CYP2C9, CYP2C19)
Summary
Nonsteroidal anti-inflammatory drugs (NSAIDs)-is one of highly used drugs, taken by 30 million of people every day. The popularity and high use of NSAIDs is explained by their significant analgetic and anti-inflammatory effect in treatment of arthritis and other acute or chronic diseases of muscloskeletal system and pain syndroms of differnet genesis [1,2,3]. High selective ingibitors of the 2nd type of cyclooxygenase provoke less expressed injuries of gastroduodenal zone, than non-selective NSAIDs, that inhibit the 1st type of cyclooxygenase and the 2nd type of cyclooxygenase as well. They don’t solve the hole problem [4,5,6]
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