Abstract
BackgroundTo explore the relationship between CYP4F2 gene polymorphism and coronary heart disease (CHD) in a Chinese Han population.MethodsWe selected 440 CHD patients and 440 control subjects to perform a case - control study. Four SNPs (rs2108622, rs3093100, rs3093105 and rs3093135) in CYP4F2 gene were genotyped using polymerase chain reaction - restriction fragment length polymorphism (PCR - RFLP) methods. The genotype and haplotype distributions were compared between the case and the control group.ResultsWe found both rs2108622 and rs3093105 in CYP4F2 gene were associated with the risk for CHD (P <0.01). Haplotype analysis indicated that GGGT haplotype consisted by rs2108622-rs3093100-rs3093105-rs3093135 was associated with CHD risk (OR = 4.367, 95% CI: 2.241 ~ 8.510; P < 0.001), but GGTA haplotype was associated with decreased risk for CHD (OR = 0.450, 95% CI: 0.111 ~ 0.777; P <0.001).ConclusionCYP4F2 gene polymorphisms were associated with the risk of CHD in Chinese population.
Highlights
Coronary heart disease (CHD) is one of the most common diseases to influence the human health
The characteristics of participants There were no significant difference in the distribution of age, BMI, HDL-C and LDL-C between the coronary heart disease (CHD) group and the control group
Genotype and allele frequencies We found GG genotype frequency of rs2108622 were significantly higher in the CHD patients than that in control group (P
Summary
Coronary heart disease (CHD) is one of the most common diseases to influence the human health. CHD was a complex polygenic disease resulting from the interaction between genetic variations and environmental factors [2]. The exact genetic mechanism is unclear, some new susceptibility gene of the CHD have been reported recently, such as apolipoprotein (Apo) E [3], CYP8A1 [4], C5L2 [5], and interleukin (IL)-1 [6]. Grammer et al [3] analyzed the association between the apo E genotype, CRP and angiographic coronary artery disease (CAD). The concentration of CRP was similar in patients with stable CAD and in controls, but increased. To explore the relationship between CYP4F2 gene polymorphism and coronary heart disease (CHD) in a Chinese Han population
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