Abstract
Phenazepam® is prescribed to relieve anxiety and sleep disorders during alcohol withdrawal, although it is associated with undesirable side effects. Aim: To demonstrate changes in the safety and efficacy profiles of Phenazepam in patients with anxiety disorders and comorbid alcohol use disorder. Materials & methods: A total of 94 Russian patients with alcohol use disorder received 4.0mg of Phenazepam per day in tablets. We used a urinary 6-beta-hydroxycortisol/cortisol ratio to evaluate CYP3A activity. Results: A statistically significant inverse correlation between Phenazepam plasma concentration and CYP3A activity was found (r=-0.340 and p=0.017). Correlation between the concentration/dose ratio and phenotyping results was also statistically significant (r=0.301 and p=0.026). Conclusion: The safety and efficacy of Phenazepam depend on CYP3A genetic polymorphisms.
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