Abstract
：Objective To explore theinfluences of Jinganning decoction on the content of CYP2E1 and cytokine IL-6,TNF in ratsmodels of alcohdic hepatic injury.Methos 72 male Wistar clean level rats were randomlydivided into 6 groups:blank control group,Jiuganning drug toxicity test group,alcoholichepatic disease model group,Yiganling treatment group,Jiuganning low dose group,andJiuganning high dose group.Blank control group was treated with physiologicalsaline;Jiuganning drug toxicity test group was treated with Jiuganning decoction toobserve toxicity and side effects.Jiuganning low and high dose treatment group weretreated with 17.5 g/kg and 23.5 g/kg crude drug.Yiganning treatment group were treatedwith 0.206 g/kg crude drug.After 4 weeks'treatment,the content of TNF,IL-6,MDA as well asthe activity of CYP2E1 and SOD were measured.Results Compared with the alcoholic hepaticdisease model group,the content of IL-6(F=46.281,9.101),TNF and the activity (F=62.537)ofCYP2E1 of all treatment group were significantly improved(P＜0.01).The content of SOD(F=19.210)in the rats serum of alltreatment group was significantly increased while the MDA(F=34.952)was decreased.All theindexes in the treatment group had significant differences with the alcoholic hepaticdisease and model group(P＜0.01).Conclusions The mechanism of Jiuganning decoction can effectively reducethe content of CYP2E1 and IL-6,TNF-a,with the changes of cell physiopathology and theinfluences of relevant enzymes,reveals the functional routines of the decoction treatinghepatic injury:anti-lipid peroxidative,adjusting cytokine's activity,protectinghepatocyte,palliating the hepatocyte inflammation,and easing fibration. Key words: Jiuganning decoetion; Alcoholic hepatitis; Oxidative stress; Lipid peroxidation
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
