Abstract
Endoxifene, one of two active metabolites that mediate tamoxifen's therapeutic effects, is formed through the action of the CYP2D6 enzyme. Several polymorphisms of the CYP2D6 gene that influence the enzyme's activity and, therefore, endoxifene levels, have been indentified. However, studies designed to uncover the link between patient response to tamoxifen and CYP2D6 enzyme activity (or CYP2D6 genotype) have yielded inconsistent results, perhaps as a result of limited sample sizes. By generating …
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