CYP2C8 and CYP2E1 genetic variants increase risk of tuberculosis in northwest Chinese Han population.

Abstract

Tuberculosis (TB) is a chronic infectious disease which remains a main cause of death worldwide, and arises more and more concerns in recent years. CytochromeP450 (CYP450) is involved in the metabolism of many exogenous and endogenous compounds, and its polymorphism is associated with many diseases. The objective of our study was to explore the relationship between CYP450 polymorphisms and TB susceptibility in Northwest Chinese Han population. 506TB patients and 506 controls were recruited for our study, and their DNA were extracted. Six single nucleotide polymorphisms (SNPs) were selected for genotype. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated to evaluate the correlation between SNPs and TB risk. The genotype "TA" of CYP2C8 rs2275620 was related to an increased risk of TB in the co-dominant model (OR=1.33, 95%CI =1.00-1.76, p=0.049). In females, CYP2E1 rs2070672 was related to an increased TB susceptibility (co-dominant: OR=1.62, 95%CI=1.04-2.52, p=0.032; dominant: OR=1.66, 95%CI=1.08-2.56, p=0.020; additive: OR=1.60, 95%CI=1.08-2.36, p=0.018), and CYP2E1 rs2515641 was also associated with an increased risk of TB (co-dominant: OR=1.90, 95%CI=1.19-3.04, p=0.007; dominant: OR=1.94, 95%CI=1.23-3.05, p=0.004; additive: OR=1.80, 95%CI=1.20-2.71, p=0.005) in women. But there was no statistical significance between haplotypes and TB risk (p>0.05). Our research showed CYP2C8 and CYP2E1 polymorphisms are associated with an increased risk of TB in Northwest Chinese Han population, which may provide a crucial help on defining new therapeutic strategies for chemoprevention.