Abstract
BackgroundEvidence indicates that CYP1A1 MspI polymorphism might be a possible risk factor for several malignancies. A growing body of literature has been devoted to the association of CYP1A1 MspI polymorphism with acute myeloid leukemia (AML). However, the results remain conflicting. The aim of the present study was to derive a more precise estimation of the relationship.MethodsMeta-analyses assessing the association of CYP1A1 MspI variation with AML were conducted and subgroup analyses on ethnicity and age groups were further performed. Eligible studies were identified for the period up to May 2012.ResultsA total of ten case–control studies including 1330 cases and 3688 controls were selected for analysis. The overall data failed to indicate a significant association of CYP1A1 MspI polymorphism with AML risk (C vs T: OR = 1.13; 95%CI = 0.87-1.48; CC vs TT: OR = 1.72; 95%CI = 0.99-3.01; CC + TC vs TT: OR = 1.16; 95%CI = 0.86-1.55). In subgroup analysis stratified by ethnicity, significant AML risk was shown among Asians (CC + TC vs TT: OR = 1.33; 95%CI = 1.09-1.62) but not Caucasians or mixed races. In subgroup analysis regarding age groups, no associations were observed in either the childhood AML or the adult AML subgroups.ConclusionThe results of the present study suggested that CYP1A1 MspI polymorphism might be a risk factor for AML among Asians. Further investigations are needed to confirm the conclusions.
Highlights
Acute myeloid leukemia (AML), known as acute nonlymphocytic leukemia (ANLL), is the most common acute leukemia mostly affecting adults, characterized by the rapid growth of abnormal white blood cells in the bone marrow and impaired production of normal blood cells
Evidence suggests that radiation, smoking, obesity and exposure to chemical carcinogens are considered as its possible risk factors [1]
Literature search strategy We carried out a search in the Medline, EMBASE, OVID, Sciencedirect, and Chinese National Knowledge Infrastructure (CNKI) without a language limitation, covering all publications published up to May 2012, with a combination of the following keywords: Cytochrome P450 1A1, CYP1A1, T3801C, MspI, acute myeloid leukemia, acute nonlymphocytic leukemia, hematology, malignancy, neoplasm, cancer, variation and polymorphism
Summary
Acute myeloid leukemia (AML), known as acute nonlymphocytic leukemia (ANLL), is the most common acute leukemia mostly affecting adults, characterized by the rapid growth of abnormal white blood cells in the bone marrow and impaired production of normal blood cells. Evidence suggests that radiation, smoking, obesity and exposure to chemical carcinogens are considered as its possible risk factors [1]. AML only develops in a small proportion of people exposed to these environmental and lifestyle risk factors, Several genetic polymorphisms have been determined as possible risk factors for leukemia by meta-analyses. Polymorphic MTR A2756G has been shown to decrease acute leukemia risk [5]. Different genetic polymorphisms might exert different effects on leukemia risk. Only a few gene polymorphisms associated with leukemia susceptibility have been identified to date. Evidence indicates that CYP1A1 MspI polymorphism might be a possible risk factor for several malignancies. A growing body of literature has been devoted to the association of CYP1A1 MspI polymorphism with acute myeloid leukemia (AML). The aim of the present study was to derive a more precise estimation of the relationship
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