Abstract
Objective: Previous studies have reported that Ile462Val polymorphism in the gene Cytochrome P450 1A1 (CYP1A1) is associated with the risk of cervical cancer, but inconsistent results have emerged. Hence, we performed this updated and cumulative meta-analysis to ascertain a more accurate association between CYP1A1 Ile462Val polymorphism and risk of cervical cancer.Methods: Studies involving the CYP1A1 Ile462Val polymorphism associated with cervical cancer risk were searched from the databases of PubMed, Scopus, ScienceDirect, and Chinese National Knowledge Infrastructure (CNKI). The strength of correlation was evaluated through calculating summary odds ratios (ORs) with the corresponding 95% confidence intervals (95% CIs). Subgroup analyses according to ethnicity, source of control and HWE were completed to further explore specific association between the polymorphism and the cancer risk.Results: Altogether, 11 eligible case-control studies were ultimately encompassed into the current meta-analysis, with 1,932 patients and 2,039 healthy controls. The total analysis revealed a borderline relationship between CYP1A1 Ile462Val polymorphism and cervical cancer risk in general population. Interestingly, after subgroup analyses based on ethnicity and source of control, the polymorphism increased the susceptibility of cervical cancer in Caucasian (G vs. A: OR = 1.97, 95% CI = 1.24–3.13; GG vs. AA: OR = 3 .24, 95% CI = 1.24–8.46; GA vs. AA: OR = 1.62, 95% CI = 1.25–2.10; GA+GG vs. AA: OR = 1.68, 95% CI = 1.16–2.43; GG vs. AA+GA: OR = 2.73, 95% CI = 1.05–7.10) and population-based (G vs. A: OR = 1.49, 95% CI = 1.10–2.02; GA vs. AA: OR = 1.41, 95% CI = 1.20–1.67; GA+GG vs. AA: OR = 1.40, 95% CI = 1.19–1.64) groups.Conclusion: The CYP1A1 Ile462Val polymorphism may enhance the susceptibility to cervical cancer in Caucasian females.
Highlights
Cervical cancer is followed by breast cancer, which is the first common cancer among women all over the world (Denslow et al, 2012)
After subgroup analyses based on ethnicity and source of control, the polymorphism increased the susceptibility of cervical cancer in Caucasian (G vs. A: odds ratios (ORs) = 1.97, 95% confidence intervals (95% confidence intervals (CIs)) = 1.24–3.13; GG vs. AA: OR =3 .24, 95% CI = 1.24–8.46; GA vs. AA: OR = 1.62, 95% CI = 1.25–2.10; GA+GG vs. AA: OR = 1.68, 95% CI = 1.16–2.43; GG vs. AA+GA: OR = 2.73, 95% CI = 1.05–7.10) and population-based (G vs. A: OR = 1.49, 95% CI = 1.10–2.02; GA vs. AA: OR = 1.41, 95% CI = 1.20–1.67; GA+GG vs. AA: OR = 1.40, 95% CI = 1.19–1.64) groups
The Cytochrome P450 1A1 (CYP1A1) Ile462Val polymorphism may enhance the susceptibility to cervical cancer in Caucasian females
Summary
Cervical cancer is followed by breast cancer, which is the first common cancer among women all over the world (Denslow et al, 2012). Besides the onset of cervical cancer was aged 15–49 years in developing countries (Forouzanfar et al, 2011). Cervical cancer is a major threat to woman’s health and quality of life, and is the focal point and the difficulties for medical workers. To seek the risk factor and people who may be at high risk of cervical cancer for prevention is a significant and important work. As we know, smoking (Sood, 1991; Zeng et al, 2012) and human papillomavirus (HPV) infection (Patel et al, 2016) are the classical risk factor for cervical cancer. Some women without smoking and HPV infection got cervical cancer, why? That’s might be other factors play a role in the onset of cervical cancer, such as genetic background Some women without smoking and HPV infection got cervical cancer, why? That’s might be other factors play a role in the onset of cervical cancer, such as genetic background
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