CYP17 T27C polymorphism and prostate cancer risk: a meta-analysis based on 31 studies

Bingbing Wei,Yunyun Zhang,Bo Xi,Junkai Chang,Jinming Bai,Jiantang Su

doi:10.1016/s1674-8301(10)60033-4

Abstract

Objective The cytochrome P450 17α-hydroxylase (CYP17) plays a vital role in androgen biosynthesis. A T-to-C polymorphism in the 5′ promoter region of CYP17 has been implicated as a risk factor for prostate cancer, but the results of individual studies are inconclusive or controversial. To derive a more precise estimation of the relationship, we performed an updated meta-analysis from 31 studies based on 27 publications. Methods A comprehensive search was conducted to examine all the eligible studies of CYP17 polymorphism and prostate cancer risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Results Overall, individuals with CC/CT genotype were not associated with prostate cancer risk (CC vs. TT: OR = 1.03, 95% CI = 0.86–1.24, P = 0.72, P heterogeneity < 0.0001; CT vs. TT: OR = 0.99, 95% CI = 0.87–1.12, P = 0.88, P heterogeneity = 0.0006). In the stratified analysis by ethnicity, there was a significantly increased risk of prostate cancer among individuals of African descent under the recessive model (OR = 1.56, 95% CI = 1.01–2.39, P = 0.04, P heterogeneity = 0.65). Conclusion This meta-analysis suggested that CYP17 polymorphism might be associated with prostate cancer risk among individuals of African descent.

Highlights

Prostate cancer (PCa) is one of the most common causes of cancer-related death among men in Western countries[1,2]
A total of 27 articles were retrieved based on the above search criteria for PCa susceptibility related to cytochrome P450 17α-hydroxylase (CYP17) T27C polymorphism
Several studies have shown that the CYP17 27C allele may be associated with increased risk of prostate cancer

Summary

INTRODUCTION

Prostate cancer (PCa) is one of the most common causes of cancer-related death among men in Western countries[1,2]. Genetic variation in one particular gene in this pathway, the cytochrome P450 17α-hydroxylase (CYP17), has been studied extensively in relation to gonadal development and the synthesis of androgens and estrogens[5]. In an attempt to resolve these contradictory results, a metaanalysis of all available studies[11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37] relating the T27C polymorphism of the CYP17 gene to the risk of developing PCa is presented here

MATERIALS AND METHODS

Statistical methods

RESULTS

DISCUSSION

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