Abstract
Background Aldosterone synthase (CYP11B2) T-344C gene polymorphism was found to be correlated with atrial fibrillation (AF) risk. However, the results of individual studies remain conflicting.Objective and methodsA meta-analysis including 2,758 subjects from six individual studies was performed to explore the correlation between CYP11B2 T-344C gene polymorphisms and AF. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were evaluated by the fixed– or random–effects model.ResultsA significant relationship between CYP11B2 T-344C gene polymorphism and AF was found under allelic (OR: 1.26, 95% CI: 1.11–1.42, P = 0.0002), recessive (OR: 1.99, 95% CI: 1.26–3.14, P = 0.003), dominant (OR: 0.903, 95% CI: 0.820–0.994, P = 0.036), homozygous (OR: 1.356, 95% CI: 1.130–1.628, P = 0.001), and additive (OR: 1.153, 95% CI: 1.070–1.243, P = 1.0×10−10) genetic models. No significant association between CYP11B2 T-344C gene polymorphism and AF was found under the heterozygous genetic model (OR: 1.040, 95% CI: 0.956–1.131, P = 0.361).ConclusionsA significant association was found between CYP11B2 T-344C gene polymorphism and AF risk. Individuals with the C allele of CYP11B2 T-344C gene polymorphism have higher risk for AF.
Highlights
Atrial fibrillation (AF) is the most common and damaging arrhythmia in clinical practice
A significant relationship between CYP11B2 T-344C gene polymorphism and atrial fibrillation (AF) was found under allelic (OR: 1.26, 95% confidence intervals (95% confidence intervals (CIs)): 1.11–1.42, P = 0.0002), recessive (OR: 1.99, 95% CI: 1.26–3.14, P = 0.003), dominant (OR: 0.903, 95% CI: 0.820–0.994, P = 0.036), homozygous (OR: 1.356, 95% CI: 1.130–1.628, P = 0.001), and additive (OR: 1.153, 95% CI: 1.070–1.243, P = 1.0610210) genetic models
No significant association between CYP11B2 T-344C gene polymorphism and AF was found under the heterozygous genetic model (OR: 1.040, 95% CI: 0.956–1.131, P = 0.361)
Summary
Atrial fibrillation (AF) is the most common and damaging arrhythmia in clinical practice. The prevalence of AF increases with age, from 0.5% of people in their 50s to nearly 10% of the octogenarian population [1]. In China, morbidity related to AF is 0.77% in the adult population [2]. AF causes chronic heart failure, tachycardia-induced cardiomyopathy, and increased thrombosis risk, especially cerebral embolism. AF patients have a higher risk for stroke than non-AF individuals. 15% of stroke cases are caused by AF. AF is the first independent risk factor for ischemic stroke in patients more than 75 years old [3]. Aldosterone synthase (CYP11B2) T-344C gene polymorphism was found to be correlated with atrial fibrillation (AF) risk. The results of individual studies remain conflicting
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