Abstract
Abstract Cynandione A (CA) is a major ingredient of Cynanchum wilfordii. Here, we report a new function of CA in adipogenesis in 3T3-L1 cells, a preadipocyte cell line. During adipogenic differentiation in 3T3-L1 cells, CA boosted the process by enhancing the expression of key adipogenic transcription factors (Pparg and C/ebpa), brown adipocyte-related genes (Prdm16, Pgc-1a, Cidea, and Ucp1), and beige adipocyte-related genes (Tbx1 and Cited1). Additionally, CA increased mitochondrial mass and expression levels of mitochondria-related genes (Sirt3 and Tfam) in the cells. These results suggest that CA induces adipogenesis and beige adipocyte-related phenotype in adipocyte lineage cells.
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