Abstract
Cynanchum paniculatum Radix, known as Xuchangqing in Chinese, is commonly prescribed in Chinese Medicine (CM) for the treatment of various inflammatory diseases. The anti-inflammatory property of Cynanchum paniculatum can be traced from its wind-damp removing, collaterals' obstruction relieving, and toxins counteracting effects as folk medicine in CM. This paper systematically reviewed the research advancement of the pharmacological effects of Cynanchum paniculatum among a variety of human diseases, including diseases of the respiratory, circulatory, digestive, urogenital, hematopoietic, endocrine and metabolomic, neurological, skeletal, and rheumatological systems and malignant diseases. This review aims to link the long history of clinical applications of Cynanchum paniculatum in CM with recent biomedical investigations. The major bioactive chemical compositions of Cynanchum paniculatum and their associated action mechanism unveiled by biomedical investigations as well as the present clinical applications and future perspectives are discussed. The major focuses of this review are on the diverse mechanisms of Cynanchum paniculatum and the role of its active components in inflammatory diseases.
Highlights
Cynanchum paniculatum (Xuchangqing in Chinese, Figures 1(a)) has been used as folk medicine by Chinese medicine (CM) practitioners for more than two thousand years to treat various inflammatory diseases. e earliest record of Cynanchum paniculatum traced back to Shennong’s Materia Medica Classic, which is the oldest Chinese pharmacopeia compiled in the Han Dynasty about 100Anno Domini (AD)
In response to inflammatory stimuli, cytokines can act through Toll-like receptors and MAPK pathways leading to activation of nuclear factor-κB (NF-κB). ree major groups of distinctly regulated mitogen-activated protein kinase cascades commonly altered inhuman diseases are extracellular signal-regulated kinases (ERK1/2), mitogen-activated protein kinase p38 (p38 MAPK), and c-Jun N-terminal kinase (JNK)
Our results showed a significant improvement of anterior tibial artery intima-media thickness (IMT), posterior tibial artery IMT, dorsalis pedis artery IMT, blood viscosity, fibrinogen, plasma D-dimer, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (P < 0.05)
Summary
Cynanchum paniculatum (Xuchangqing in Chinese, Figures 1(a)) has been used as folk medicine by Chinese medicine (CM) practitioners for more than two thousand years to treat various inflammatory diseases. e earliest record of Cynanchum paniculatum traced back to Shennong’s Materia Medica Classic, which is the oldest Chinese pharmacopeia compiled in the Han Dynasty about 100. Cynanchum paniculatum (Xuchangqing in Chinese, Figures 1(a)) has been used as folk medicine by Chinese medicine (CM) practitioners for more than two thousand years to treat various inflammatory diseases. Pharmacological research shows that the chemical composition or extract of Cynanchum paniculatum has analgesic, sedative, anti-inflammatory, antibacterial, antiallergic, and anticancer effects [3, 8,9,10]. The advances in the traditional application, phytochemistry, pharmacology, and the current research progress of Cynanchum paniculatum on treating various diseases are systematically reviewed. E terms and keywords for searching included Xuchangqing, Cynanchum paniculatum, anti-inflammation, studies mechanism, pharmacology, toxicology, and in vivo. We did not identify any previous review article regarding the anti-inflammatory effect, the application in inflammatory diseases, and safety Cynanchum paniculatum until the completion of this paper
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Evidence-Based Complementary and Alternative Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
