Cylinders or walls? A new computational model to estimate the MR transverse relaxation rate dependence on trabecular bone architecture

Abstract

Bone density is distributed in a complex network of interconnecting trabecular plates and rods that are interspersed with bone marrow. A computational model to assess the dependence of the relaxation rate on the geometry of bone can consider the distribution of bone material in the form of two components: cylinders and open walls (walls with gaps). We investigate whether the experimentally known dependence of the transverse relaxation rate on the trabecular bone structure can be usefully interpreted in terms of these two components. We established a computer model based on an elementary computational cell. The model includes a variable number of open walls and infinitely long cylinders as well as multiple geometric parameters. The transverse relaxation rate is computed as a function of these parameters. Within the model, increasing the trabecular spacing with a fixed trabecular radius is equivalent to thinning the trabeculae while maintaining constant spacing. Increasing the number of cylinder and wall gap elements beyond their nearest neighbors does not change the transverse relaxation rate. Although the absolute contribution to the relaxation due to open walls is on average more important than that due to cylinders, the latter drops off rapidly. The change on transverse relaxation rate is larger for changing cylinder geometry than for changing wall geometry, as it can be seen from the effect on the relaxation rate when trabecular spacing is varied, compared to varying the size of wall gaps. Our results provide strong evidence that trabecular thinning, which is associated with increasing age, decreases the relaxation rates. The effect of thinning plates and rods on the transverse relaxation can be understood in terms of simple cylinders and open walls. A reduction in the relaxation rate can be seen as an indication of thinning cylinders, corresponding to reduced bone stability and ultimately, osteoporosis.