Abstract
Abstract This chapter provides an overview of methods for the analysis of cyclotides, a structurally unique class of plant defense peptides. These peptides have been extensively analyzed over the last two decades, having been discovered in the Violaceae, Rubiaceae, Cucurbitaceae, Fabaceae, and Solanaceae plant families. Cyclotides are characterized by their distinctive head‐to‐tail cyclic peptide backbone and the cystine knot formed by their three conserved disulfide bonds. Cyclotides exhibit a range of activities, including insecticidal, anti‐HIV, antimicrobial, and cytotoxic activities, and are thus of interest for applications in drug design and agriculture. We here report on methods for their discovery and characterization, as well as methods for their quantification in plant tissues and biofluids.
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