Abstract
OBJECTIVE: To determine the response of Cyclosporine versus Cyclophosphamide in childhood nephrotic syndrome. PLACE AND DURATION: Nephrology Unit, National Institute of Child Health, Karachi, from April - September 2012. STUDY DESIGN: Prospective Comparative study. METHODS: 158 patients aged 6 months to 15 years with either steroid resistant (SR) or steroid dependent nephrotic syndrome (SDNS) were randomly assigned to receive either cyclosporine (CS –arm) or cyclophosphamide (CP-arm ) for 3 months along with alternate day prednisolone. Treatment response and side effects were monitored clinically and by laboratory tests (spot urine protein–creatinine ratio in both arms, serum creatinine in CS-arm and complete blood counts in CP-arm). Outcome was defined after 12 weeks as complete remission (CR), partial remission and resistance. Data including demographics, type of NS, treatment response and adverse effects were collected and analyzed on SPSS-16. RESULTS: There were 79 patients in each arm. Mean age in both arms was almost identical (6.8±3.9 and 6.9±3.7 years). Among 158, 87(55%) were SD and 71(45%) were SRNS. Majority (78.5%) in CS-arm achieved CR compared to 34.2% in CP- arm. This is highly significant (p value
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of Liaquat University of Medical & Health Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.