Abstract
delineated by Parks et a1.6 include (1) the tense, woody fibrosis; (2) irregularly shaped ulcers, some extending to expose muscle; (3) a halo of'hyperpigmentaion surrounding the ulcers; and (4) the apparent indifference of the patients toward the disfiguring process and their lack of expression of pain despite the degree of tissue destruction. Several reports have described the typical pentazocine abuser as middle-aged, college-educated, married, and associated with the health professions. Often there is a history of alcohol or drug abuse or psychiatric illness.Patients with a personal or family history of diabetes may also be at special risk for cutaneous complications' The exact mechanism by which injection of pentazocine induces cutaneous and muscle changes is unknown. There is histologic evidence of vascular thrombosis with dermal and epidermal infarction. Other authors'' postulate that precipitation of pentazocine in tissue incites an inflammatory response.
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