Abstract
Objective. To review the benefits and limitations of cyclosporine concentration monitoring to maximize efficacy of graft-versus-host disease prophylaxis and minimize risk of cyclosporine toxicity.Data Sources. A CANCERLIT search of articles published from 1980 to 1995, using the MESH head ings cyclosporine, and marrow transplant. References listed in the identified publications were reviewed for additional pertinent literature.Study Selection. Human clinical trials and re view articles evaluating cyclosporine pharmacokinet ics and pharmacodynamics in patients status follow ing bone marrow transplantation.Data synthesis. Cyclosporine concentration monitoring has been proposed due to the critical need for drug efficacy, substanial drug-induced toxic ity, and high pharmacokinetic variability. Selection of biological fluid (blood, serum, or plasma) for moni toring as well as the selectivity of the assay employed for cyclosporine versus its metabolites, is a critical factor in evaluating this literatu...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
