Abstract
Cyclosporine-induced childhood generalized hypertrichosis
Highlights
Hypertrichosis is defined as disproportionate hair growth in body areas with no action of androgen hormones and shows no effects of race, age, and gender.[1]
There was a recent worsening of proteinuria, so pediatric nephrology decided to increase the dosage of Cyclosporin A (CsA) to 5 mg/kg/day
Cyclosporin is an immunosuppressive, calcineurin inhibitor whose mechanism of action is to selectively inhibit the function of the helper T lymphocytes (CD4+), blocking the production of interleukins, especially IL-2.3 It is widely used in dermatology, including the treatment of psoriasis and atopic dermatitis[4] and in other specialties, such as steroid-resistant nephrotic syndrome
Summary
Hypertrichosis is defined as disproportionate hair growth in body areas with no action of androgen hormones and shows no effects of race, age, and gender.[1]. Among the main adverse effects of dermatological interest are hypertrichosis, gingival hyperplasia, increased incidence of cutaneous neoplasia and infections.[5]
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