Cyclophosphamide-induced bladder cancer.

Abstract

Letters1 January 1997Cyclophosphamide-Induced Bladder CancerJan Gossmann, MDJan Gossmann, MDKlinikum der J.W. Goethe-Universitat; Frankfurt, Main, GermanySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-1-199701010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The study by Talar-Williams and colleagues [1] on cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis, which had an extensive follow-up on a large group of patients, may help define the incidence of clinically detectable bladder cancer in these patients. However, the authors' statement that nonglomerular hematuria is a risk factor for this disease may be biased because only patients with nonglomerular hematuria had cystoscopy; the other 72 patients in the cohort did not. Therefore, the true incidence of bladder cancer or cyclophosphamide-induced bladder injury in those 72 patients remains unknown, because in as many ...