Abstract
Intraperitoneal administration of 100 mg/kg cyclophosphamide resulted in an increase of both sodium preference and consumption by rats given a choice between water and saline (0.15 M) to drink. Measurement of serum sodium concentration revealed that the cyclophosphamide-treated animals had lower values, thus indicating that the cyclophosphamide-elicited sodium appetite was caused by a drug-induced need for sodium.
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