Abstract
Scutianene E ( 1), 3,4,28-tris- epi-scutiaene E ( 2), 28- epi-scutianene E ( 3) and scutianene L ( 4), four neutral cyclopeptide alkaloids, were isolated from Scutia buxifolia Reiss, together with four known cyclopeptide alkaloids, scutianines B, C, D and E. Scutianenes 1– 3 are diastereoisomeric compounds, with 3-hydroxyleucine as a β-hydroxy amino acid unit, which is connected to the styryl fragment via an ether bridge, β-phenylserine, as a common ring-bonded amino acid residue. Attached to the amino group of β-hydroxyamino acid is a side chain [ trans-CH = CH–Ph]. The structures of the peptides were elucidated by means of spectroscopic analysis, including extensive 2D NMR studies. The stereochemistry for the diastereomeric 3,4,28-tris- epi-scutiaene E and 28- epi-scutianene E was confirmed by X-ray diffraction analysis of their O-acetyl derivatives.
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