Abstract
AbstractCyclopentadienyl tricarbonyl 99mTc octanoic acid (99mTc‐CpTOA; 1) was prepared in high radiochemical yield (40–63%) and shown to be stable (90% at 6 h) in human serum. Biological studies demonstrated longer retention and slower metabolism of 99mTc‐CpTOA in CCl4‐treated mice than in normal mice, possibly due to impaired β‐oxidation. These results along with good water solubility of the radioactive extracts from the liver indicated that this radiotracer was mainly metabolized via β‐oxidation in the liver. This study thus suggests that 99mTc‐CpTOA 1 holds promise for evaluation of fatty acid metabolism in the liver.
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Schedule a callMore From: Journal of Labelled Compounds and Radiopharmaceuticals
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