Abstract
To evaluate relationship between the cyclooxygenase-2 promoter 765G/C polymorphism and digestive cancer risk in China. A literature search through February 2014 was performed using PubMed, Chinese Biomedical Literature Database (CBM) and China National Knowledge Infrastructure (CNKI) databases, and a meta-analysis was performed with RevMan 5.2 software for odds ratios and 95%CIs. In total, 9 articles with 3,263 cases and 4,858 controls were included in this meta-analysis.The pooled OR (95%CIs) in the co-dominant model (GC vs GG) was 1.56 [1.19, 2.06], and in the dominant model ((CC+GC) vs GG), the pooled OR was 1.59 [1.21, 2.09] in overall cancers. In the subgroup analysis, stratified by cancer type, significant associations were found that the-765C allele had increased pancreatic cancer and gastric risk. No significant liver cancer and colorectal cancer risk of COX-2 -765G/C polymorphism was found. These findings suggest that COX-2-765*C is related to cancer susceptibility and may increase gastric and pancreatic cancer risk.
Highlights
It has been suggested that environmental factors and genetic predisposition may affect the individual’s susceptibility and play an important role in the development of tumors (Cocos et al, 2012; Rubin et al, 2012; Arzumanyan et al, 2013; Hardbower et al, 2013), though the risk attributable to each is unclear
Publication search Relevant studies were identified by searching the electronic literature on PubMed, Chinese Biomedical Literature Database (CBM) and China National Knowledge Infrastructure (CNKI) using search terms ‘Cyclooxygenase-2’ or ‘COX-2’, ‘polymorphism’ and ‘digestive tract cancer’ or ‘colorectal cancer’ or ‘gastric cancer’ or ‘pancreatic cancer’ or ‘liver cancer’
In the co-dominant model, we found associations of this SNP with cancer risk in overall cancer susceptibility (OR=1.56, 95%CI=[1.19, 2.06], p=0.001), gastric cancer (OR=1.75, 95%CI=[1.31, 2.32], p=0.0002), liver cancer (OR=1.03, 95%CI=[0.51, 2.07], p=0.94), colorectal cancer (OR=1.27, 95%CI=[0.62, 2.57], p=0.52), pancreatic cancer (OR=2.51, 95%CI= [1.73, 3.66], p
Summary
It has been suggested that environmental factors and genetic predisposition may affect the individual’s susceptibility and play an important role in the development of tumors (Cocos et al, 2012; Rubin et al, 2012; Arzumanyan et al, 2013; Hardbower et al, 2013), though the risk attributable to each is unclear. No significant liver cancer and colorectal cancer risk of COX-2 -765G/C polymorphism was found. We performed a meta-analysis of the published studies to derive a more precise estimation of the association between COX-2, 765G/C polymorphism and the digestive cancers susceptible risk.
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