Abstract
Objective. This study investigated the effects of single dosages of the non-steroidal anti-inflammatory drug (NSAID) naproxen, and of the coxib, rofecoxib, on the exercise-induced stress response. Design. Eight subjects (age 20.9 ± 1.1 years, weight 70.4 ± 3.9 kg, height 170.9 ± 6.7 cm, body surface area 1.82 ± 0.09 m2, body mass index 24.1 ± 1.3 kg.m-2) took part in a double-blind, drug-placebo, cross-over design study. The experimental procedures were performed on 3 occasions on each volunteer, i.e. once on placebo, once on naproxen (single dose of 1 000 mg) and once on rofecoxib (single dose of 50 mg). Results. Mean post-exercise cortisol values were significantly higher than pre-exercise values with the subjects on placebo (p = 0.0365) and rofecoxib (p = 0.0208), but not on naproxen (p = 0.0732). Post-exercise oral temperatures were significantly higher than pre-exercise temperature values on placebo (p = 0.0153) and rofecoxib (p = 0.0424), but not on naproxen (p = 0.5444). Conclusion. The results of this study suggest a role for cyclooxygenase-1 (COX-1) in the exercise-induced cortisol and temperature response to exercise. South African Journal of Sports Medicine Vol. 18 (1) 2006: pp. 4-8
Highlights
Mean post-exercise cortisol values were significantly higher than pre-exercise values with the subjects on placebo (p = 0.0365) and rofecoxib (p = 0.0208), but not on naproxen (p = 0.0732)
The results of this study suggest a role for cyclooxygenase-1 (COX-1) in the exercise-induced cortisol and temperature response to exercise
Most stressors, including heat, pain, trauma and exercise, stimulate prostaglandin synthesis. The mechanisms underlying this stimulation usually involve the release of pro-inflammatory cytokines with subsequent induction of prostaglandin synthesis which influences the central neuroendocrine regulatory mechanisms.[14]
Summary
Subjects and experimental designThe effects of the 2 NSAIDs on the exercise-induced stress response were investigated in healthy students in a doubleblind, drug-placebo, cross-over design study in which each subject served as his/her own control. All tests started at the same time of the day and experimental conditions were similar for all exposures. During the first week of the study students had general medical examinations and those with either hypertension (> 140/90 mmHg), hypotension (< 100/60 mmHg), or any other pathological condition or risk factor, as well as students on chronic medication or performance-enhancing drugs were excluded. Students who developed any health complication such as colds or flu during the study were excluded. Other than the treadmill procedures of the study no strenuous physical activity was allowed over the 4 weeks each subject was involved in the study and subjects had to refrain from alcohol intake on the days before the experiments. During the same week the maximal oxygen consumption (VO2max) of each student was determined, the procedures of the study explained and informed consent forms signed.
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