Abstract
According to the World Health Organization, the major psychiatric and neurodevelopmental disorders include major depression, bipolar disorder, schizophrenia, and autism spectrum disorder. The potential role of inflammation in the onset and progression of these disorders is increasingly being studied. The use of non-steroidal anti-inflammatory drugs (NSAIDs), well-known cyclooxygenase (COX) inhibitors, combined with first-choice specific drugs have been long investigated. The adjunctive administration of COX inhibitors to classic clinical treatments seems to improve the prognosis of people who suffer from psychiatric disorders. In this review, a broad overview of the use of COX inhibitors in the treatment of inflammation-based psychiatric disorders is provided. For this purpose, a critical analysis of the use of COX inhibitors in the last ten years of clinical trials of the major psychiatric disorders was carried out.
Highlights
According to the American Psychiatric Association, psychiatric disorders, called mental disorders or mental illnesses, are defined as health conditions involving changes in emotion, thinking, or behavior [1]
Celecoxib, a selective COX-2 inhibitor, remains the most studied drug, even if some clinical trials were accomplished by using aspirin, ibuprofen, and naproxen that show a different grade of selectivity towards the two COX isoenzymes
COX inhibitors have been found to have positive effects in the treatment of psychiatric diseases when administered in combination with first-choice specific drugs
Summary
According to the American Psychiatric Association, psychiatric disorders, called mental disorders or mental illnesses, are defined as health conditions involving changes in emotion, thinking, or behavior (or a combination of these manifestations) [1]. According to the World Health Organization (WHO), the most common mental illnesses include major depression, bipolar disorder, schizophrenia, and other psychoses, dementia, and developmental disability [2]. All these disorders affect more than 600 million people worldwide, distributed as 264 million affected by major depression, 46 million with bipolar disorders, 284 million with anxiety disorders, 20 million people with schizophrenia, and 62 million show autistic spectrum disorder (Figure 1) [2]. Molecules 2020, 25, 5388 by pathogen infections, traumatic brain injury, toxic metabolites, and autoimmunity, and. Molecules 2020, 25, x FOR PEER REVIEW by psychological stress [6,7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
