Abstract
Multi-ethnicity of Brazilian population displays high levels of genomic diversity. Polymorphism may detect people at higher risk of developing cancer, distinctive response to treatment, and prognosis. Cyclooxygenase-2 (COX-2) is induced in response to growth factors and cytokines, and is expressed in inflammatory diseases, precancerous lesions and colorectal cancer (CRC). The aim of this study was to evaluate the influence of COX-2 -1195A > G and 8473T > C polymorphisms as a risk factor of developing CRC. We evaluated COX-2 Single Nucleotide Polymorphism (SNP) of 230 CRC patients and 196 healthy controls by Real-Time Polymerase Chain Reaction. Populations were in Hardy-Weinberg equilibrium (HWE), except for control group of 8473T > C SNP. The frequencies were similar in both groups for genotypes and haplotypes. There was no association between studied polymorphisms and risk of CRC. The gene polymorphisms studied do not participate in the genetic susceptibility to CRC in a Brazilian population.
Highlights
Colorectal cancer (CRC) is considered a public health problem worldwide [1]
The multi-ethnicity of Brazilian population represents a challenge in terms of genetic variability characterization, and the intra-individual genetic variation represented by genetic polymorphisms can be a relevant factor in susceptibility to developing cancer, distinct response to jgo.amegroups.com
We evaluated the association of genotypes and alleles of the COX-2 gene between case and control groups using the χ2 test or Fisher’s exact test
Summary
Colorectal cancer (CRC) is considered a public health problem worldwide [1]. In Brazil, it was registered 15,067 death for this malignancy in 2013 [2] and the incidence is estimated at 34,280 people in 2016 [3].The multi-ethnicity of Brazilian population represents a challenge in terms of genetic variability characterization, and the intra-individual genetic variation represented by genetic polymorphisms can be a relevant factor in susceptibility to developing cancer, distinct response to jgo.amegroups.comJ Gastrointest Oncol 2017;8(4):629635 chemotherapy and radiotherapy, and prognosis [4]. The multi-ethnicity of Brazilian population represents a challenge in terms of genetic variability characterization, and the intra-individual genetic variation represented by genetic polymorphisms can be a relevant factor in susceptibility to developing cancer, distinct response to jgo.amegroups.com. The Cyclooxygenase-2 (COX-2), undetectable under normal conditions, is readily induced in response to growth and inflammatory factors, and it is expressed in inflammatory diseases, pre-malignant lesions and colorectal tumors [8]. Polymorphism may detect people at higher risk of developing cancer, distinctive response to treatment, and prognosis. Cyclooxygenase-2 (COX-2) is induced in response to growth factors and cytokines, and is expressed in inflammatory diseases, precancerous lesions and colorectal cancer (CRC). The aim of this study was to evaluate the influence of COX-2 −1195A > G and 8473T > C polymorphisms as a risk factor of developing CRC. Conclusions: The gene polymorphisms studied do not participate in the genetic susceptibility to CRC in a Brazilian population
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