Cyclooxygenase-2 gene -1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control study in Han Chinese people

Abstract

This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene promoter and evaluate their effects on the risk of primary hepatocellular carcinoma (HCC) with hepatitis B virus (HBV) infection. We conducted a population-based, case-control study enrolling 630 Han Chinese people in Hubei province. Subjects included primary HCC patients with HBV infection (n = 210), chronic hepatitis B cases (n = 210) and healthy Han Chinese (n = 210). −1195G/A polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing analysis. We found -1195A allele carriers had a higher risk of HCC with HBVinfection (OR, 0.72; 95% CI, 0.548–0.946). The −1195A allele might be used as a marker in screening individuals at high risk of HCC with HBV infection.