Abstract

New cyclic nona and octapeptides, cyclolinopeptides B - E were isolated from the seeds of Linum usitatissimum and their structures were elucidated as cyclo (-Pro-Pro-Phe-Phe-Val-Ile-Met-Leu-Ile-), cyclo (-Pro-Pro-Phe-Phe-Val-Ile-Mso-Leu-Ile-), cyclo (-Pro-Phe-Phe-Trp-Ile-Mso-Leu-Leu-), and cyclo (-Pro-Leu-Phe-Ile-Mso-Leu-Val-Phe-), respectively, by extensive 2D NMR methods and chemical degradations. Cyclolinopeptides B and E showed immunosuppressive activity. New cyclic nona and octapeptides, cyclolinopeptides B - E were isolated from the seeds of Linum usitatissimum and their structures were elucidated as cyclo (-Pro-Pro-Phe-Phe-Val-Ile-Met-Leu-Ile-), cyclo (-Pro-Pro-Phe-Phe-Val-Ile-Mso-Leu-Ile-), cyclo (-Pro-Phe-Phe-Trp-Ile-Mso-:eu-Leu-), and cyclo (-Pro-Leu-Phe-Ile-Mso-Leu-Val-Phe-), respectively, by extensive 2D NMR methods and chemical degradations. Cyclolinopeptides B and E showed immunosuppressive activity.

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