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Abstract
N6-Cyclohexyl-[ 3H]adenosine ([ 3H]CHA) binds specifically to rat brain membranes prepared from the caudate-putamen complex with a K d value of 2.50 ± 0.39nM and B max of458 ± 51fmol/mg protein. Lesioning the nigrostriatal dopaminergic pathway using 6-hydroxydopamine failed to alter [ 3H]CHA binding characteristics. Intrastriatal kainate lesions reduced the binding capacity of [ 3H]CHA by 28% though this was not statistically significant (0.1 < P > 0.05). In kainate-lesioned striata, however, 2-deoxyglucose uptake was reduced by only 39%.
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