Abstract

Cyclodextrins (CDs) are used as excipients in nasal drug formulations because they act as solubilisers and/or absorption enhancers. With several CDs very efficient nasal drug absorption has been reported, but large interspecies differences have been found. Studies concerning the safety of CDs in nasal drug formulations demonstrate the non-toxicity of the CDs and also clinical data show no adverse effects. Therefore, some CDs can be expected to become effective and safe excipients in nasal drug delivery.

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