Abstract
Cyclodextrins and their methylated derivatives were used as stationary phases in gas-solid chromatography and the effect of inclusion on the retention of compounds with various structures and geometries (alkanes, aromatic hydrocarbons, alcohols) was followed. It has been found that inclusion predominates in the gas-solid interaction of compounds with suitable geometric dimensions, while the retention of polar substances is primarily determined by the interactions with the cyclodextrin hydroxyl groups. On decreasing the cyclodextrin polarity by means of methylation, stereoselectivity was evident even in the separation of alcohols. On the other hand, the presence of methyl groups causes steric hindrance to penetration of the guest molecule into the cyclodextrin cavity. The selectivity of the inclusion process is especially important for separations of positional isomers.
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