Cyclodextrin-based dispersive liquid–liquid microextraction for the determination of fungicides in water, juice, and vinegar samples via HPLC

Abstract

Cyclodextrin-based dispersive liquid–liquid microextraction (CD-DLLME) was developed for the determination of triazole and strobilurin fungicides in water, juice, and vinegar samples using high-performance liquid chromatography-diode-array detection (HPLC-DAD). Undecanol, which is a green solvent, was selected as the extraction solvent. A cyclodextrin aqueous solution was chosen as the dispersion solvent and demulsifier to avoid the use of a toxic dispersion solvent and eliminate the centrifugation step. Dispersion and phase separation were completed within 1 and 60 s, respectively. The linear range of this method was 1 to 100 µg L−1. The limits of detection were 0.3 μg L−1 along with the preconcentration factor of 133 and enrichment factor of 124. The recovery was 83.2% to 103.2%. This pretreatment method was fast, simple, and environmentally friendly and was successfully applied to the analysis of triazole and strobilurin fungicide residues in water, juice, and vinegar samples.