Cyclodextrin‐Triazole Derivative Functionalized on Ag–SiO2 Core–Shell Nanoparticles via Click Chemistry

Abstract

Click chemistry has provided a versatile strategy for functionalization in solution chemistry under mild reaction conditions with a high degree of functional group compatibility. Initially, silver (Ag) nanoparticles were prepared by the chemical reduction method, followed by the synthesis of silver–silica (Ag–SiO2) core–shell nanoparticles by the Stöber method. The Ag–SiO2 core shell nanoparticles were functionalized with the alkyne derivative. The cycloaddition reaction between the azide‐functionalized cyclodextrin and the alkyne‐functionalized Ag–SiO2 core–shell nanoparticles was carried out via the copper‐catalyzed click reaction, leading to the formation of the cyclodextrin‐triazole derivative on the Ag–SiO2 core–shell nanoparticles. The presence of the resulting cyclodextrin‐triazole derivative on the silver–silica core–shell nanoparticles was confirmed by Fourier transform infrared spectroscopy (FT‐IR), ultraviolet–visible spectroscopy (UV–vis), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and thermogravimetric analysis (TGA).