Abstract
Amphiphilic cyclodextrins (CDs) with various lipophilic chain lengths were used as vectors for transfection of Hep G2 hepatocytes in vitro . Transgene expression increased with increasing chain length. The most efficient cyclodextrin, heptakis[6-hexadecylthio-2-(ω-deoxy-ω-amino- oligo(ethylene oxide))]-β-cyclodextrin, achieved higher levels of transfection than DOTAP. Fluorescein-labeled DNA complexes with this tetramethylrhodamine-labeled cyclodextrin vector were seen to be taken up by Hep G2 cells within 30 min and achieved luciferase expression within 4 h.
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