Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing Polygoni cuspidati Extract with Potential for Dental Applications.

Magdalena Paczkowska-Walendowska,Judyta Cielecka-Piontek,Katarzyna Winnicka,Ewa Baranowska-Wójcik,Dominik Szwajgier,Marek Simon,Emilia Szymańska,Marek A Ruchała

doi:10.3390/pharmaceutics13111916

Magdalena Paczkowska-Walendowska, Judyta Cielecka-Piontek + Show 6 more

Open Access

https://doi.org/10.3390/pharmaceutics13111916

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Abstract

Polygoni cuspidati root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for administration within the oral mucosa. To improve the solubility of resveratrol and to assure its high content in plant material, an ultrasound-assisted extraction method was applied. The addition of cyclodextrin was found to increase the extraction efficiency of resveratrol (from 13 to 297 µg per 1 g of plant material in case of 50% ethanol extracts) and enhanced its antioxidant activity as compared to pure Polygoni cuspidati extract/resveratrol. Cyclodextrin plays the role of a functional extract regarding technological properties (increasing the extraction of resveratrol from the extract, improving mucoadhesive properties). Therefore, the aim of this study was to develop mucoadhesive tablets containing combinations of the Polygoni cuspidati extract with a cyclodextrin carrier for buccal delivery. The tests sequentially included extract preparation and characterization of its physical and biological properties and then formulation studies with a broad description of the prototype properties. The test results indicate that cyclodextrin increases the efficiency of resveratrol extraction from Polygoni cuspidati rhizome, which is a rich source of resveratrol, and its extract enclosed in a mucoadhesive tablet guarantees prolonged action at the site of administration.

Highlights

NF polymer was obtained by Lubrizol (Wickliffe, OH, USA), whereas β-cyclodextrin, hydroxypropyl-β-cyclodextrin average Mw ~ 1460 (0.8–1.0 MS Molar Substitution) andmethyl cellulose (HPMC) with average Mn ~ 90,000 (~15,000 cP) and magnesium stearate were supplied by Sigma-Aldrich (Poznań, Poland)
The method was developed on three standards (RSV, emodin, parietin), but due to the low concentration of parietin in the prepared extracts, it was decided to validate the method only for two standards (RSV and emodin) (Figure 1)
The dried root and rhizome of Polygonum cuspidatum is a rich source of resveratrol, a well-known compound with strong antioxidant properties that inhibits the development of civilization diseases